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In conclusion, S-234462 exhibits insurmountable antagonism of NPY Y5 receptor in vitro and superior anti-obesity effects to the surmountable NPY Y5 antagonist S-2367 in DIO mice. Furthermore, high-fat diet-induced obese (DIO) mice treated with S-234462 for 5 weeks showed a significant decrease in body weight gain and food intake compared to those treated with S-2367. In vivo study showed that S-234462 effectively suppressed food intake induced by acute central injection of a selective Y5 receptor agonist. insurmountable: 1 adj not capable of being surmounted or overcome insurmountable disadvantages Synonyms: unsurmountable unconquerable not capable of being conquered or vanquished or overcome impossible not capable of occurring or being accomplished or dealt with insuperable, unconquerable incapable of being surmounted or excelled Antonyms. In cell-based washout experiments, S-234462 dissociated from the Y5 receptor more slowly than S-2367. Both compounds displayed high affinity for the Y5 receptor in the radio-ligand binding assay, while in the cell-based functional assay, S-2367 and S-234462 showed, respectively, surmountable and insurmountable antagonism. Here we report the discovery and characterization of two novel Y5 receptor antagonists, S-2367 and S-234462. 11 synonyms for insurmountable: insuperable, impossible, overwhelming, hopeless.
#Synonym insurmountable free
The NPY-Y5 receptor system has been an attractive drug target for potential use in treating obesity. Synonyms for UNBEATABLE: bulletproof, impregnable, indomitable, insuperable, insurmountable, invincible, invulnerable, unconquerable Antonyms for UNBEATABLE. Synonyms for insurmountable in Free Thesaurus. Situated as we are, in the United States, many, and almost insurmountable obstacles present themselves.Neuropeptide Y (NPY) Y5 receptor plays a key role in the effects of NPY, an important neurotransmitter in the control of energy homeostasis including stimulation of food intake and inhibition of energy expenditure.
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The difficulty of conveying heavy weights up the mountain foot-paths was almost insurmountable. Thus age and avarice can always over-leap barriers which, to the young and romantic, are insurmountable. I knew she believed in me and in my ability to find a solution to what seemed like an insurmountable challenge. There’s an almost insurmountable mountain to climb if you’re trying to create a good brand off a bad product. This difficulty is well-nigh insurmountable in connection with this third formula. Cette difficulté est presque insurmontable en ce qui concerne cette troisième formule. The final gaps, though, proved insurmountable and created a level of bitterness, according to their letters. In this way he has created an insurmountable problem. Some serve as a foil - a common enemy players can rally around to come together and ultimately overcome insurmountable odds. These challenges of intermittency and geography are not insurmountable-batteries and water can store energy, and better transmission systems can be built.īy the end of the summer, the anxiety had become insurmountable and he left his job. The current, anti-democratic and intellectually dishonest Republican Party is an insurmountable barrier to the development of a viable alternative to the existing Democratic Party.